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Tan Ya
Bihar, India0 followers0 following
- About
- Bachelor's
- Master's
- Target
- IELTS
Female
Bihar, India
Work ExperienceJunior Research Fellow
Indian Institute of Science Education and Research - Bhopal - Full Time
Nov 1, 2020 - Dec 31, 2020 · 2 mos
Madhya Pradesh, India
Reviewed pieces of literature on Double knot toxins (DkTx) and their role in ion
channel activation and concluded that the development of hybrid variants of DkTx will
allow investigating the mechanism of ion channel activation.
•Purified DkTx and different variants using HPLC and buffer preparations.
•Handled the culture of Xenopus laevis
ProjectsTan Ya has not added any project yet.
Research PapersQuantifying Mutational Response to track the evolution of SARS-CoV-2 Spike variants: Introducing a Statistical Mechanics-guided Machine Learning Method
Oct 13, 2022 - The Journal of Physical Chemistry B
The emergence of SARS-CoV-2 and its variants that critically affect global public health requires characterization of mutations and their evolutionary pattern from specific Variants of Interest (VOIs) to Variants of Concern (VOCs). Leveraging the concept of equilibrium statistical mechanics, we introduce a new responsive quantity defined as “Mutational Response Function (MRF)” aptly quantifying domain-wise average entropy-fluctuation in the spike glycoprotein sequence of SARS-CoV-2 based on its evolutionary database. As the evolution transits from a specific variant to VOC, we find that the evolutionary crossover is accompanied by a dramatic change in MRF, upholding the characteristic of a dynamic phase transition. With this entropic information, we have developed an ancestral-based machine learning method that helps predict future domain-specific mutations. The feedforward binary classification model pinpoints possible residues prone to future mutations that have implications for enhanced fusogenicity and pathogenicity of the virus. We believe such MRF analyses followed by a statistical mechanics augmented ML approach could help track different evolutionary stages of such species and identify a critical evolutionary transition that is alarming.
VolunteeringTan Ya has not added any volunteering detail yet.